High-voltage irradiation and combination chemotherapy for malignant pheochromocytoma

Treatment of malignant pheochromocytoma with combination chemotherapy.

Three patients with rapidly progressive, disseminated malignant pheochromocytoma were treated with a combination chemotherapeutic regimen consisting of cyclophosphamide, vincristine, and dacarbazine in repeated 21- to 28-day cycles. All three patients had a marked decrease in blood pressure and an improvement in performance status within the first few cycles of treatment. At a follow-up of 6 to...

Combination chemotherapy regimen in a patient with metastatic malignant pheochromocytoma and neurofibromatosis type 1

PATIENT Female, 55 FINAL DIAGNOSIS: Metastatic malignant pheochromocytoma Symptoms: Chest pain • tachycardia • tachypnea MEDICATION - Clinical Procedure: - Specialty: Oncology. OBJECTIVE Rare disease. BACKGROUND Malignant pheochromocytoma is defined as the occurrence of the tumor in an area that is normally devoid of chromaffin tissue, direct tumor invasion, and/or metastasis. Metastatic ...

Intensive Combination Chemotherapy and X-Irradiation in Hodgkin's Disease.

See related article by Moxley et al., Cancer Res 1967;27:1258–63. This article was a pilot study of the first attempt to cure an advanced solid tumor, in this case Hodgkin disease, with combination chemotherapy (1). It was very controversial. Virtually no one at the time believed it was possible to cure cancer with drugs. Furthermore, it was a general tenet ofmedicine then that drugs, for any d...

Chemotherapy in Ovine Malignant Theileriosis

Malignant Catatonia Mimicking Pheochromocytoma

Malignant catatonia is an unusual and highly fatal neuropsychiatric condition which can present with clinical and biochemical manifestations similar to those of pheochromocytoma. Differentiating between the two diseases is essential as management options greatly diverge. We describe a case of malignant catatonia in a 20-year-old male who presented with concurrent psychotic symptoms and autonomi...